Aging Gracefully Part. 3: The Potential of Rapamycin in Extending Your Aging Pet's Lifespan!4/24/2024 Introduction: Aging Process in PetsThis is another episode of the Aging Gracefully series. I've been learning so much from the relatively new concept: Anti-aging. I hope you've been enjoying it too. As pet owners, we all want our furry friends to live long, healthy, and happy lives. One of the struggles I have in my career, veterinary medicine, is that it has become "normal" to have cancers in aging pets, and many veterinarians don't expect animals, especially dogs, to live longer. I have worked with several vets who expect their own pets to die around 9 years old. Isn't it sad? My Newfoundland mix lived until 14 years old. Why do you think it's great if your Golden or Pointer lives up to only 9 years old? By the way, have you ever wondered why we and our pets age? What is aging? Is aging a disease? I think we can agree that aging is a natural process that occurs in all living beings. As we and our pets get older, our and their bodies undergo various changes that can affect overall health and well-being. One of the key factors in the aging process is the gradual decline in the body's ability to repair and regenerate cells. This decline can lead to a decrease in organ function, weakened immune systems, and an increased susceptibility to diseases. Instead of focusing on aging itself, I believe we should focus on how to help our and their bodies regain normal function. Anyway, aging definitely increases the body's dysfunctionality. So, let's dive into another finding of anti-aging. Common Health Issues in Older Dogs and CatsAs our pets grow older, they may begin to exhibit specific signs that suggest the passage of time. In dogs, common signs include gray hair, decreased energy levels, difficulty in getting up or moving around, weight gain or loss, changes in appetite, and a decline in hearing and vision. Cats, on the other hand, may exhibit similar signs such as reduced activity, weight changes, changes in litter box habits, dental problems, and an increased need for grooming. It's important to note that these signs may vary from one pet to another, and some pets may age more gracefully than others. However, if you notice any significant changes in your pet's behavior or health, it's always a good idea to consult with your veterinarian. The Potential of Rapamycin in Extending Your Pet's LifespanNow, let's talk about rapamycin - a drug that has shown immense potential in extending the lifespan of our aging pets. Originally developed as an immunosuppressant for humans, rapamycin has been the subject of extensive research in recent years due to its remarkable anti-aging properties. Rapamycin works by inhibiting a protein called mTOR, which is responsible for regulating cell growth and metabolism. By inhibiting mTOR, rapamycin slows down the aging process and promotes cellular repair and regeneration. This can lead to improved organ function, enhanced immune system response, and a longer, healthier life for our pets. How Rapamycin Works to Slow Down Aging in PetsTo understand how rapamycin works its magic, we need to delve a bit deeper into the science behind it. As our pets age, the activity of mTOR (mammalian target of rapamycin) increases, leading to an imbalance in cellular processes. This imbalance can result in the accumulation of damaged cells and proteins, which ultimately contribute to the aging process. Rapamycin steps in by inhibiting mTOR, restoring the balance in cellular processes. This allows cells to effectively clear out damaged components and repair themselves, promoting overall health and longevity. By slowing down the aging process, rapamycin can potentially extend the lifespan of our aging pets and improve their quality of life. Research Studies on the Effects of Rapamycin in Animal StudiesNumerous animal studies have been conducted to evaluate the effects of rapamycin on aging in animals. One such study published in 2021 showed that rapamycin treatment in mice resulted in an increased lifespan of up to 25%. The mice also showed improved cardiac function and a reduced incidence of age-related diseases. Another study conducted on dogs by the University of Washington demonstrated similar promising results. The dogs treated with rapamycin showed improved cardiac function compared to the control groups. While these studies are certainly promising, it's important to note that rapamycin is currently only approved for human use and further research is needed to determine the optimal dosage and potential side effects in pets. Potential Side Effects and Precautions of Using RapamycinAs with any medication, there are potential side effects and precautions to consider when using rapamycin for your aging pet. Some common side effects reported in human studies include gastrointestinal issues, increased risk of infections, changes in blood sugar levels, and changes in cholesterol levels. It's crucial to work closely with your veterinarian if you're considering rapamycin for your pet. They can determine the appropriate dosage and monitor your pet for any adverse effects. It's also important to note that rapamycin should never be administered without the supervision of a veterinarian, as improper use can lead to serious health complications. Natural food that can Inhibit mTOR like RapamycinWhile rapamycin shows great potential in extending the lifespan of our aging pets, it's not the only option available. There are natural foods that can inhibit mTOR, similar to how rapamycin does. These foods include broccoli, spinach, green tea, turmeric, apple, strawberries, cucumbers, and resveratrol-rich foods like grapes (please don't give grapes to your pets though) and blueberries. Incorporating these foods into your pet's diet may help promote cellular health and slow down the aging process. However, it's important to consult with your veterinary professionals before making any significant changes to your pet's diet, as individual dietary needs may vary. Other Lifestyle Changes to Support Your Aging Pet's HealthIn addition to considering rapamycin or incorporating mTOR-inhibiting foods, there are other lifestyle changes you can make to support your older pet's health. Regular exercise tailored to their abilities, mental stimulation through interactive toys and puzzles, and providing a comfortable and safe environment can all contribute to their overall well-being. Of course, a lot of attention and love help! It's also essential to schedule regular check-ups with your veterinarian to monitor your pet's health, address any concerns, and discuss appropriate preventive care measures. ConclusionAs pet owners, we have the power to make a significant impact on the health and well-being of our aging pets. While the potential of rapamycin in extending their lifespan is an exciting discovery, it's important to approach it with caution and consult with a veterinarian. Additionally, incorporating mTOR-inhibiting foods and implementing other lifestyle changes can also contribute to their overall health and happiness. Remember, your furry friend relies on you to provide the best care possible. If you're interested in changing your aging pet's health with natural food and supplements, please schedule an appointment with me. Together, we can give the best care to your beloved companion and ensure they live gracefully for years to come! References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190242/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/ https://www.nature.com/articles/s41586-021-04282-9.epdf?sharing_token=Or2NwrHAQGR4496myNqgDNRgN0jAjWel9jnR3ZoTv0N8TmD_nbRjd-31o8sL8H8iX54DkLtmyeaUyzrRUkq8wo44RFz_Rp0LVyQvSXKO2Sa3VQ9tSClq7ci0u619zzbtjikW1VEL10GnEQLIrP8_S7MF6d-HxYg4zXnF1dmwQ_c%3D https://newsroom.uw.edu/news-releases/dog-aging-project-resource-scientists-many-fields
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Introduction to Nicotinamide Adenine Dinucleotide (NAD+) As pet owners, we all want our furry companions to live long, happy, and healthy lives. But as our pets age, they may start experiencing various health problems. One key factor in the aging process is a decline in cellular energy production. This is where Nicotinamide Adenine Dinucleotide (NAD+) comes into play. NAD+ is a coenzyme found in every living cell and is crucial for energy metabolism. In this article, we will explore the role of NAD+ in cellular energy production and its potential benefits for older pets. The Role of NAD+ in Cellular Energy Productio NAD+ plays a vital role in cellular energy production by acting as a cofactor in several metabolic reactions, such as glycolysis and oxidative phosphorylation. These processes are responsible for converting the food our pets eat into energy that their cells can use. As our pets age, the levels of NAD+ in their bodies decline, leading to decreased energy production and potentially contributing to the onset of age-related health issues Understanding the Aging Process in Pets Just like humans, pets undergo the aging process. As they grow older, their bodies undergo various physiological changes. These changes can include a decrease in muscle mass, a decline in organ function, and a decrease in the efficiency of their immune systems. Additionally, aging pets may experience joint problems, such as arthritis, and an increased susceptibility to diseases. By understanding the aging process, we can better address the specific health needs of our older pets. Common Health Problems in Older Cats and Dogs Older cats and dogs are prone to certain health problems. In cats, arthritis and renal failure are common issues. It can significantly impact their quality of life. Dogs, on the other hand, may experience various age-related health problems, including arthritis, cognitive decline, and reduced immune function. These health issues can be distressing for both pets and their owners. Fortunately, NAD+ supplementation may offer some relief. Benefits of NAD+ for Older Pets Managing Pain and Arthritis in Senior Dogs with NAD+ Arthritis is a prevalent condition in senior dogs, affecting their joints and causing discomfort. NAD+ has been shown to have anti-inflammatory properties, making it a potential natural option for managing pain and inflammation associated with arthritis. By increasing NAD+ levels in their bodies, we can potentially reduce the symptoms of arthritis in senior dogs, improving their mobility and overall quality of life. Improving Joint Health in Senior Cats with NAD+ Arthritis is also a common problem in senior cats. The loss of cartilage in their joints can lead to pain and stiffness. Fortunately, NAD+ may help improve joint health in senior cats. By increasing NAD+ levels, we can potentially reduce inflammation, support cartilage regeneration, and alleviate the discomfort associated with arthritis. This can greatly enhance the mobility and overall well-being of our senior feline companions. Choosing the Best NAD+ Supplements for Pets Several substances, known as precursors, have the potential to elevate NAD+ levels in the body. These precursors are obtainable through supplements or dietary sources. The following are some of the precursors that can increase NAD+ levels:
When considering NAD+ supplementation for our older pets, it is essential to choose the right supplements. Look for reputable brands that offer high-quality products specifically formulated for pets. Consider supplements that contain other beneficial ingredients, such as antioxidants and joint-supporting compounds. It's also a good idea to consult with your veterinarian to ensure that the supplement is appropriate for your pet's specific needs and health condition. Natural Foods that Increase NAD+ for Pets In addition to supplements, certain natural foods can help increase NAD+ levels in pets. Foods rich in Tryptophan and niacin, such as beef and fish, can provide precursors for NAD+ synthesis. Other foods, like broccoli, cabbage, avocado, and mushrooms, contain compounds that support NAD+ production. Including these foods in your pet's diet can be a natural and delicious way to boost their NAD+ levels and support their overall health. Potential Risks of Increasing NAD+ Level When it comes to boosting NAD+ levels in older pets through diet changes and supplements, it's important to be cautious. There are some risks to be aware of. These include:
Just like with any changes to your pet's diet, it's crucial to introduce new supplements gradually and keep a close eye on how your pet responds. Some pets might have allergies or sensitivities, so it's important to watch out for any negative reactions. It's generally safer to focus on getting NAD+ precursors from a balanced, natural food diet rather than using high-dose supplements. This approach can help minimize the potential risks associated with NAD+ elevation in older pets. Additionally, it's always a good idea to consult with your veterinarian before making any significant changes to your pet's diet. Conclusion The Potential of NAD+ for Improving the Health of Older Pets As our pets age, they may experience a decline in cellular energy production, leading to various health problems. Nicotinamide Adenine Dinucleotide (NAD+) plays a crucial role in cellular energy metabolism and can potentially alleviate age-related issues in older pets. By managing pain and arthritis in senior dogs, improving joint health in senior cats, and incorporating NAD+-boosting foods and supplements into their diets, we can enhance the well-being and quality of life of our aging furry companions. If you're interested in exploring the benefits of NAD+ for your older pet, contact me to schedule an appointment and discuss the best options for your furry friend's specific needs. Need Help?Interested in incorporating natural sources of NAD+ into their diet or exploring NAD+ supplements specifically formulated for pets? If you feel your pet could benefit from natural food and herbal care including mushrooms, consider scheduling an appointment with me. I’m happy to help you and your furry friend! If you haven't already, don't forget to subscribe to the newsletter! You'll receive exclusive updates on special events, discounts, and much more. This is only available to newsletter subscribers. Resources:
https://www.verywellhealth.com/nad-supplements-7966461 https://link.springer.com/article/10.1007/s13668-023-00475-y https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30495-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413116304958%3Fshowall%3Dtrue https://pubmed.ncbi.nlm.nih.gov/24014409/ https://www.mdpi.com/2072-6651/13/1/50 https://www.sciencedirect.com/science/article/abs/pii/S0531556519307582?via%3Dihub https://ard.bmj.com/content/82/Suppl_1/836. |
AuthorYuki Konno MS, LVT, CVWHM(civt) Archives
November 2024
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